In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 934-22-5 as follows. Recommanded Product: 6-Aminobenzimidazole
To a stirred solution of 5-amino-benzimidazole (290mg, 2. 2MMOL) in anhydrous DMF (lOmL) under N2 was added caesium carbonate (980mg) The resulting mixture was stirred at 70C for 60 min. To this was added a solution of 6-CHLORO-N-[(15)-1-PHENYLETHYL] PYRAZIN-2-AMINE (470mg) in DMF (5mL) and the resulting mixture was then heated at reflux for 48h. The DMF was removed under reduced pressure and the residue diluted with chloroform. The organic layer was washed with aqueous NA2CO3, dried (NA2SO4) and the solvent removed under reduced pressure to furnish the crude product. Column chromatography using dichloromethane-methanol (95: 5 No. 92: 8) as eluant separated two fractions from unreacted starting material. The higher Rf fraction was assigned as the 6-isomer (276mg, 42%). 1H-n. m. r. (CDCl3) 81. 64 (d, 3H, J= 6.9Hz, CH3), 2.90 (br s, 2H, NH2), 5.05 (m, 1H, CH), 5.21 (d, 1H, NH), 6.70 (dd, 1H, /= 8.7, 2. 1Hz, benzimid-H), 6.97 (d, 1H, J = 1. 8Hz, benzimid-H), 7.28-7. 43 (m, 5H, Ph-H), 7.58 (d, 1H, J= 8.4Hz, benzimid-H), 7.84 (s, 1H, pyraz-H), 8.08 (s, 1H, pyraz-H), 8.21 (s, 1H, benzimid-H). m/z (ES) 331 (M++H). The lower fraction was assigned as the 5-isomer (170mg, 26%),’H-n. m. r. (CDCl3) 81. 64 (d, 3H, J= 6. 9HZ, CH3), 2.85 (BR S, 2H, NHZ), 5.01 (m, 1H, CH), 5.19 (d, 1H, NH), 6.70 (dd, 1H, J= 8.7, 2. 1Hz, benzimid-H), 7.11 (d, 1H, J= 1. 8Hz, benzimid-H), 7.29-7. 40 (m, 5H, Ph-H), 7.51 (d, 1H, YE8. 7Hz, benzimid-H), 7.81 (s, 1H, pyraz-H), 8.10 (s, 1H, pyraz-H), 8.32 (s, 1H, benzimid-H). m/z (ES) 331 (M++H).
According to the analysis of related databases, 934-22-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; CYTOPIA PTY LTD; WO2003/99811; (2003); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem