Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1402838-08-7, name is 2-(1-Trityl-4-imidazolyl)benzaldehyde, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 2-(1-Trityl-4-imidazolyl)benzaldehyde
In the atmosphere of nitrogen,Dimethyl methylphosphonate (402 mg, 3.24 mmol, 1.5 equiv)Dissolved in 5 ml of dry tetrahydrofuran.Cool to -60C with dry ice/ethanol.n-Butyllithium (1.70 ml, 2.5 mol/ml n-hexane solution, 4.32 mmol, 2 eq.) was slowly added dropwise.The mixture is stirred at this temperature for 30 minutes.The compound 6-fluoro-2-methylbenzofuran-5-carboxylic acid methyl ester (0303-69) (450 mg, 2.16 mmol, 1 eq.) was slowly added dropwise.A solution of tetrahydrofuran (5 ml).The mixture was stirred at this condition for 1 hour. Isopropanol (15 ml), cesium carbonate (1.0 g, 3.24 mmol, 1.5 eq) and 2-(1-Tri) were addedBenzyl-1H-imidazol-4-yl)benzaldehyde (0105-1) (894 mg, 2.16 mmol, 1 eq.) stirred at room temperatureAfter 16 hours, after the reaction was completed, water (50 ml) was added and the mixture was extracted with ethyl acetate. The organic phase was washed with saturated brine and anhydrous sulfuric acid.The sodium was dried, concentrated under reduced pressure, and purified by silica gel column chromatography to give the product 1-(6-fluoro-2-methylbenzofuran-5-yl)-3-(2-(1-trityl-1H-imidazol-4-yl)phenyl)prop-2-en-1-one (530 mg, yield 41.9%).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1402838-08-7.
Reference:
Patent; Guangzhou Bi Beite Pharmaceutical Co., Ltd.; Cai Xiong; Qian Changgeng; Weng Yunwo; Qing Yuanhui; Liu Bin; Lin Mingsheng; Wang Yanyan; (126 pag.)CN107383024; (2017); A;,
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