Adding a certain compound to certain chemical reactions, such as: 106429-57-6, name is Methyl 2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carboxylate, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 106429-57-6, COA of Formula: C9H8N2O3
A suspension of benzimidazolone 2 (25.0 g, 0.130 mol, 1 eq) in POCl3 (150 mL) was heated to reflux for 7 h. The excess of POCl3 was evaporated and the residue was neutralized with saturated NaHCO3 solution. The precipitate was collected by filtration and dried in vacuo. The aqueous phase was extracted with DCM, dried over MgSO4 and the solvent was removed under reduced pressure. The light brown solids obtained this way were of high purity and could be used in the next step without further purification (19.7 g, 93.6 mmol, 72 %).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carboxylate, and friends who are interested can also refer to it.
Reference:
Article; Zellmann, Felix; Thomas, Laura; Scheffer, Ute; Hartmann, Roland K.; Goebel, Michael W.; Molecules; vol. 24; 4; (2019);,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem