Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 50995-95-4, name is 2-Propylimidazole, A new synthetic method of this compound is introduced below., COA of Formula: C6H10N2
Copper (I) Iodide (0.038g) and D-histidine (0.062g) in DMSO (15ml) was stirred under an atmosphere of argon at 11O0C for 30 minutes when 3-(4-bromophenyl)-1 ,4- diazaspiro[4.5]dec-3-en-2-one (D6) (0.614g), 2-propylimidazole (264mg) and potassium carbonate (0.553g) was added and heating was continued at 11 O0C for 5 days when the mixture was poured into a mixture of sodium bicarbonate solution and ethyl acetate. The mixture was stirred for 2 hours, filtered and the filtrate was separated. The ethyl acetate layer was dried over sodium sulphate, evaporated and the residue was chromatographed on a silica column eluted with 0-5% 2M methanolic ammonia/DCM to give the title compound (0.2g).1H NMR (CDCI3) delta: 1.4 (3H, t), 1.5 – 1.85 (obs, m), 1.9 – 2.1 (4H, m) 2.7 (2H, t), 7.00 (1 H, m), 7.09 (1 H, m), 7.4 (2H, m), 7.82 (1 H, br), 8.55 (2H, m). Mass Spectrum (LC/MS): Found 337 (MH+). Ret. time 1.87 min.
The synthetic route of 50995-95-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXO GROUP LIMITED; WO2009/34061; (2009); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem