These common heterocyclic compound, 137049-00-4, name is 1-Methyl-1H-imidazole-4-sulfonyl chloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 137049-00-4
To a precooled (0 C) solution of intermediate 2.93 (20. mg, 0.066 mmol) in dichloromethane (0.5 mL) was added triethylamine (30 muL, 0.2 mmol) and 1-methyl-1H- imidazole-4-sulfonyl chloride (18 mg, 0.098 mmol). The resulting mixture was allowed to warm to room temperature and stirred for 15 h, then diluted with wet DMSO (0.5 mL), filtered through Celite and purified via mass-directed isolation using ultra-performance liquid chromatography (15 mg, 52% yield).1H NMR (500 MHz, Acetonitrile-d3) d 8.85 (s, 1H), 7.77- 7.65 (m, 2H), 7.53 (dd, J = 12.3, 1.5 Hz, 2H), 7.39 (t, J = 8.5 Hz, 1H), 7.32- 7.24 (m, 1H), 7.21- 7.10 (m, 2H), 7.10- 7.02 (m, 1H), 4.36 (dd, J = 13.3, 4.3 Hz, 1H), 3.68- 3.58 (m, 4H), 3.06- 2.94 (m, 1H), 2.94- 2.86 (m, 2H); AMM 449.0869 (ESI) m/z [calc for C20H19ClFN4O3S (M+H)+ 449.0850]. (0467)
The synthetic route of 1-Methyl-1H-imidazole-4-sulfonyl chloride has been constantly updated, and we look forward to future research findings.
Reference:
Patent; THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA; VAL-CHUM, LIMITED PARTNERSHIP; GRENIER, Melissa Carey; SMITH, Amos B., III; FINZI, Andres; DING, Shilei; CHAPLEAU, Jean-Philippe; (240 pag.)WO2020/28482; (2020); A1;,
Imidazole – Wikipedia,
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