Related Products of 6160-65-2, These common heterocyclic compound, 6160-65-2, name is 1,1′-Thiocarbonyldiimidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A flask was charged with (8S,10R,llS,12S,13R,14S)-12-hydroxy-ll-(4- methoxyphenyl)- 10,13 -dimethy 1-2, 6,7, 8,9, 11,12,14,15,16-decahy dro- 1 H- cyclopenta[a]phenanthrene-3,17-dione (Step H) (270 mg, 0.66mmol) and azeotroped with toluene. DCM (7 mL) was added, followed by triethylamine (0.28mL, 1.98mmol, 3 eq), and di(imidazol-l-yl)methanethione (1.18 g, 6.61mmol, 10 eq). The reaction was stirred under argon at rt for one day, then another portion of di(imidazol-l-yl)methanethione (1.1 g) was added. After another day, another 700 mg of di(imidazol-l-yl)methanethione was added. The reaction was stirred for 2 more days. Then the reaction was quenched with diluted HCl (chromatography to give the title compound (265 mg, 77%). m/z (ESI, +ve ion) 541.3 (M+Na)+.
Statistics shows that 1,1′-Thiocarbonyldiimidazole is playing an increasingly important role. we look forward to future research findings about 6160-65-2.
Reference:
Patent; ORIC PHARMACEUTICALS, INC.; SUN, Daqing; MCGEE, Lawrence R.; DU, Xiaohui; ZHU, Liusheng; YAN, Xuelei; REW, Yosup; EKSTEROWICZ, John; MEDINA, Julio C.; ZHOU, Haiying; BALBAS, Minna Delarae; FANTIN, Valeria R.; (98 pag.)WO2017/112909; (2017); A1;,
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