Adding a certain compound to certain chemical reactions, such as: 52099-72-6, name is 1-(Prop-1-en-2-yl)-1H-benzo[d]imidazol-2(3H)-one, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 52099-72-6, Application In Synthesis of 1-(Prop-1-en-2-yl)-1H-benzo[d]imidazol-2(3H)-one
1-isopropenylbenzimidazolone 1.74 g (0.01 mol)And 0.72 g (0.01 mol) of acrylic acid were placed in a 100 mL reaction flask,30 mL of dried methylene chloride was added,Stir to complete dissolution, add 0.2 mL of triethylamine.And then weighed three phosgene 1.19g (0.004moL) dissolved in dry 10mL dichloromethane,Ice bath slowly drop in the reaction bottle.After the dropwise addition, the reaction system was returned to room temperature,Continue to stir 5 ~ 8h, after the end of the reaction,To the reaction system was added 20 mL of a saturated aqueous solution of sodium hydrogencarbonate,Full shock after the static phase separation, the organic phase washed with water, magnesium chloride drying,Degassed under reduced pressure and purified by silica gel column chromatography (eluent petroleum ether / ethyl acetate = 4/1)To give 2.11 g of the title compound (yield 92.5%),
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(Prop-1-en-2-yl)-1H-benzo[d]imidazol-2(3H)-one, and friends who are interested can also refer to it.
Reference:
Patent; Institute of Pesticide Science,Northwest A & F University(NWAFU); Ji, Zhiqin; Wu, Wenjun; Wei, Shaopeng; (9 pag.)CN102816121; (2016); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem