Electric Literature of 1632-83-3, A common heterocyclic compound, 1632-83-3, name is 1-Methylbenzimidazole, molecular formula is C8H8N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1-rnethylbenzimidazole (11) (5.0 g, 37.8 mrnol) and N-bromosuccinimide (20.2 g, 113.5 mmol) in 200 mL of THF was heated under reflux for I h. The solvent was removed in rotary evaporator and the residue was recrystallized from EtOAc yielding 8 (7.4 g, 93%) as a white solid. ?H NMR (DMSO-d6) 6 7.77 (d, 1H), 7.65 (d, IH), 7.39 (m, 2H), 3.86 (s, 3H); ?3C NMR (DMSOd5) 6 138.2, 135.4, 131.5, 124.8,124.7, 117.0, 112.3, 33.0; HRMS (ESIQTOF): ni/z Calcd for C8H7N2Br + H: 210.9871, found: 210.9911.
The synthetic route of 1632-83-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; VIRGINIA COMMONWEALTH UNIVERSITY; GUPTON, Frank; MARTIN, Alex; SIAMAKI, Ali; BELECKI, Katherine; (28 pag.)WO2016/89845; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem