Reference of 120781-02-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 120781-02-4 as follows.
To the solution of 1.8 g methyl 2-bromo-3-methyl-imidazole-4-carboxylate in mixture ofTHF:MeOH (20 ml_ : 20 mL) at 0C was added a solution of 0.7 g LiOH in H20 (20 mL). After the addition was completed reaction mixture was stirred at 0C for 1 h. Reaction mixture was concentrated under reduced pressure and was diluted with 20 mL of water, acidified with solid KHSO4 and compound was extracted with EtOAc (20 ml x 2). The combined organic layer was washed with brine, dried over Na2S04and concentrated under reduced pressure to afford the title compound as colorless oil (1.5 g, 89.0% yield).1H NMR (400 MHz DMSO-d6): d 7.61 (s, 1 H), 3.82 (s, 3 H).
According to the analysis of related databases, 120781-02-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BASF SE; GOCKEL, Birgit; SOERGEL, Sebastian; KOERBER, Karsten; (152 pag.)WO2019/137995; (2019); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem