In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1792-40-1, name is 2-Methyl-5-nitro-1H-benzo[d]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 2-Methyl-5-nitro-1H-benzo[d]imidazole
General procedure: Conventional Method. A solution of KOH (0.01mol) in water (20 mL) and CS2 (0.01 mol) was added to solution of 4a-d (0.01 mol) in ethanol (20 mL) and then, the mixture was refluxed for 4 hours. After the reaction was completed, monitored by TLC (Ethyl acetate: Hexane, 3:1), the mixturewas cooled down to room temperature and neutralized with diluted HCl (4N). The mixture was left to cool down and the precipitated product was filtrated, washed with H2O andrecrystallized from ethanol. Microwave Method. A solution of 4a-d (0.01 mol) in ethanol(10 mL) and KOH (0.01 mol) in water (5 mL) were taken in a microwave process vial. Then, the mixture was heated under microwave irradiation 300 Watt at 100 C, with stirring and air-jet cooling for 5 min. After the mixture was cooled down, CS2 (0.01 mol) was added to the mixture and then, heated again 300 Watt at 100 C. Completion of reaction was achieved in 10 min. as indicated by TLC. Then, the mixture was neutralized with 4 N HCl and left to cool. The precipitated product was filtrate, washed with H2O and recrystallized from ethanol. 5-[(2-Methyl-5(6)-nitro-1H-benzimidazole-1-yl)methyl]-1,3,4-oxadiazole-2-thiol (5a) M.p. 249-250 C. IR (KBr), nu/cm-1: 3021, 2968, 2698, 1618,1518, 1343, 1250, 1145. 1H-NMR (DMSO-d6, 200 MHz) delta: 14.22 (s, 1H, SH), 8.44 (s, 1H, Ar-H), 8.18 (d, 1H, Ar-H,J=8.8), 7.86 (d, 1H, Ar-H, J=8.8), 5.71 (s, 2H, CH2), 2.42 (s,3H, CH3) ppm. 13C NMR (DMSO-d6, 50 MHz) delta: 14.29, 43.24, 111.38, 115.09, 118.64, 136.14, 142.14, 143.66,157.43, 159.50, 178.73 ppm. Anal. Calcd. For C11H9N5O3S: C, 45.36; H, 3.11; N, 24.04; S, 11.01; Found: C, 45.38; H,3.13; N, 24.05; S, 11.02; ESI-MS: m/z: 292 [M]+.
The synthetic route of 1792-40-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Kahveci, Bahittin; Sosan, Nesibe; Mentese, Emre; Yilmaz, Fatih; Revue Roumaine de Chimie; vol. 58; 6; (2013); p. 511 – 515;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem