In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 716-79-0, name is 2-Phenyl-1H-benzo[d]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 716-79-0
General procedure: To a solution of TBZ (1.0 equiv) (for TBZ-10, 11, 12, 13, 18) or 2-phenyl-1H-benzo[d]imidazole (1.0 equiv) (for TBZ-20) with sodium hydride (1.2 equiv) in DMF for 15 min, then corresponding iodomethane, benzyl bromide, 4-methoxybenzylchloride, 3-nitrobenzyl bromide, 5-(chloromethyl)-1,2,3-trimethoxybenzene(1.0 equiv) was added slowly at room temperature. On completion of the reaction monitored by TLC, the solvent was evaporated and the residue was purified by silica gel chromatography by DCM/MeOH system to afford the final product.
The synthetic route of 716-79-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Zhang, Chao; Zhong, Bo; Yang, Simin; Pan, Liangkun; Yu, Siwang; Li, Zhongjun; Li, Shuchun; Su, Bin; Meng, Xiangbao; Bioorganic and Medicinal Chemistry; vol. 23; 13; (2015); p. 3774 – 3780;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem