Adding a certain compound to certain chemical reactions, such as: 68282-53-1, name is 5-Methyl-1H-imidazole-4-carbaldehyde, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 68282-53-1, COA of Formula: C5H6N2O
COMPOUND 12.1.40: N,N-DIETHYL-4-[6-METHOXY-2-[(5-METHYL-1H- IMIDAZOL-4-YL) METHYLI-‘7-(2-MORPHOLIN-4-YLETHOXY)-1, 2, 3, 4- TETRAHYDROISOQUINOLIN-1-YLBENZAMIDE; To a solution of INTERMEDIATE 7.1. 3 (22 mg, 0.0471 mmol) in anhydrous 1,2- dichloroethane (1 mL) was added 4-methyl-lH-imidazole-5-carbaldehyde (10 mg, 0.0909 mmol, 1.9 eq). After stirring for 5 min, sodium triacetoxyborohydride (29.8 mg, 0.141 mmol, 3 eq) was added in one lot. The reaction mixture was stirred at RT for 48hr, then quenched with saturated aqueous sodium bicarbonate (0.8 mL) and extracted with dichloromethane (2 x 10 mL). Excess aldehyde was removed by stirring the extracted dichloromethane with polymer supported hydrazine for 2 hr. The polymer was filtered off and the filtrate was concentrated and dried under vacuum. Product was purified by flash chromatography, using Si02 column with MeOH/DCM (10: 90) gave 24.6 mg (0. 0438 mmol, 93%) of COMPOUND 12.1. 40 as oil. 1H NMR (500 MHz, CDC13) : No. 1.15 (br s, 3H), 1.28 (br s, 3H), 2.13 (s, 3H), 2.51 (m, 4H), 2.58 (m, 1H), 2.69 (m, 2H), 2.75 (m, 1H), 2.90 (m, 1H), 3.08 (m, 1H), 3.30 (br s, 2H), 3.40 (m, 1H), 3.55 (br s, 2H), 3.60 (m, 1H), 3.69 (m, 4H), 3.70 (s, 3H), 3.85-3. 95 (m, 2H), 4.58 (s, 1H), 6.23 (s, 1H), 6.62 (s, 1H), 7. 28-7. 34 (m, 4H). 13C NMR (125 MHz, CDC13) : 6 10. 96,13. 10,14. 10,27. 96,39. 69,43. 66,46. 56,49. 03, 50.84, 54.26, 56.13, 67.08, 67.35, 111. 81, 114.92, 126.59, 127.94, 128.96, 129.92, 132.83, 136.37, 145.20, 146.72, 148.79, 171.47. (+) LRESIMS m/z 562 (M+H) +.
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Reference:
Patent; ASTRAZENECA AB; WO2005/61484; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem