The important role of 37067-95-1

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 37067-95-1.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 37067-95-1, name is 2-Iodo-1-methyl-1H-imidazole, This compound has unique chemical properties. The synthetic route is as follows., category: imidazoles-derivatives

A suspension of compound 38 (1.38g; 3.46mmol), 2-iodo-1 -methyl-1 H-imidazole (0.45g; 2.16mmol) and Et3N (3.0mL; 21.6mmol) in DMSO (25ml_) was degassed under N2. Dichlorobis(triphenylphosphine)-palladium (304mg; 0.43mmol) and copper(l) iodide (41 mg; 0.22mmol) were added and the reaction mixture was stirred at 90C for 1 .5 hours. The reaction mixture was cooled to room temperature, poured onto waterand extracted with EtOAc. The organic layer was decanted, washed with brine, dried (MgS04), filtered and evaporated to dryness. The residue was purified bychromatography over silica gel (Irregular SiOH, 15-40mueta”, 300g MERCK; mobile phase, 0.4% NH4OH, 96% DCM, 4% MeOH). The pure fractions were collected and evaporated to dryness. The residue (780mg) was then purified by achiral super critical fluid chromatography on (2 AMINO 6muetaiota 150×21 .2mm; mobile phase, 0.3% 2-propylamine, 80% C02, 20% MeOH). The pure fractions were collected and evaporated to dryness, yielding 430mg (41 %) of compound 300. This fraction was taken up with CH3CN. The precipitate was filtered off and dried yielding 377mg (36%) of compound 300. MP=192C (DSC).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 37067-95-1.

Reference:
Patent; ASTEX THERAPEUTICS LIMITED; SAXTY, Gordon; MURRAY, Christopher William; BERDINI, Valerio; BESONG, Gilbert Ebai; HAMLETT, Christopher Charles Frederick; JOHNSON, Christopher Norbert; WOODHEAD, Steven John; READER, Michael; REES, David Charles; MEVELLEC, Laurence Anne; ANGIBAUD, Patrick Rene; FREYNE, Eddy Jean Edgard; GOVAERTS, Tom Cornelis Hortense; WEERTS, Johan Erwin Edmond; PERERA, Timothy Pietro Suren; GILISSEN, Ronaldus Arnodus Hendrika Joseph; WROBLOWSKI, Berthold; LACRAMPE, Jean Fernand Armand; PAPANIKOS, Alexandra; QUEROLLE, Oliver Alexis Georges; PASQUIER, Elisabeth Therese Jeanne; PILATTE, Isabelle Noelle Constance; BONNET, Pascal Ghislain Andre; EMBRECHTS, Werner Constant Johan; AKKARI, Rhalid; MEERPOEL, Lieven; WO2011/135376; (2011); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem