These common heterocyclic compound, 3012-80-4, name is 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 3012-80-4
1.00 Mmol of n-methyl benzimidazole-2-formaldehyde (a,0.1700g) adding into a reaction kettle of 15 ml of polytetrafluoroethylene, adding 10 ml of methanol to dissolve, and then adding 0.5 mmol of ferrous chloride (0.0811g), wherein 0.25 mmol of 2-aminomethyl pyridine (b and 26 mu l) is added under the condition of stirring), continuously stirring for 3 minutes, sealing, and putting into a baking oven at the temperature of 140 DEG c for heat preservation for 48 hours, and then slowly cooling to obtain a red blocky crystal (about 10 hours to be reduced to the room temperature)), wherein the yield is 71percent (based on b).
The synthetic route of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Guangxi Normal University; Zeng Minghua; Zhu Zhonghong; (18 pag.)CN108164566; (2018); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem