Reference of 52099-72-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 52099-72-6, name is 1-(Prop-1-en-2-yl)-1H-benzo[d]imidazol-2(3H)-one belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
1) added to the three-opening bottle -1 – 1, 3 – dihydro – 2H – (1 – methyl vinyl) benzimidazolone (10 g, 0.06 muM), N, N – dimethyl formamide (50 ml) and NaOH (4.6 g, 0 . 11 muM); dropwise 1, 2 – Dibromoethane (21.5 g, 0 . 11 muM), in the 25 – 30 C under stirring 4 hours; after the reaction is completed, water and ethyl acetate, separating the organic phase; the aqueous phase is extracted with ethyl acetate. The combined organic phase washing, drying, filtering, the concentrated oil of 1, 3 – dihydro -1 – (2 – bromomethyl) -3 – (isopropenyl) – 2H – benzimidazolone 13.9 g (purity 90.8%, yield is 86.2%)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(Prop-1-en-2-yl)-1H-benzo[d]imidazol-2(3H)-one, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Suzhou Kelun Pharmaceutical Co., Ltd.; Sichuan Kelun Pharmaceutical Institute Co., Ltd.; Zhao Fulu; Zhang Yong; Cui Hua; Ma Changpeng; Wang Lichun; Wang Jingyi; (16 pag.)CN107235913; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem