Discovery of 615-15-6

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Methyl-1H-benzo[d]imidazole, its application will become more common.

Related Products of 615-15-6,Some common heterocyclic compound, 615-15-6, name is 2-Methyl-1H-benzo[d]imidazole, molecular formula is C8H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 8; Synthesis of N-4-lH-benzimidazol-2-yl-N-5-(2,4-dimethylphenyl)-2-methyl-lH-imidazole-4,5-dicarboxamide; Synthesis of 2-Methyl-4,5-imidazoledicarboxylic acid; [00177] 2-Methylbenzimidazole (5 g, commercially available from Aldrich) was added to a mixture of concentrated sulfuric acid (55 mL) and water (55 mL) at 90 0C. This was followed by the addition of potassium dichromate (37 g). After 15 – 20 minutes, the mixture was cooled to room temperature and diluted with 1 L of water, which was then kept overnight at room temperature. The resulting solid was filtered off, washed with cold water and air dried to give 4 g of 2-methyl-4,5- imidazoledicarboxylic acid which was used without any further purification. 1H-NMR (DMSO-rfd): delta 2.46 (s, 3H). MS (EI): 171 (MH+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Methyl-1H-benzo[d]imidazole, its application will become more common.

Reference:
Patent; EXELIXIS, INC.; WO2008/42282; (2008); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem