In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 96797-15-8, name is 4-Iodo-1-trityl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 96797-15-8
Step 1: Preparation of 2-chloro-5-(1-trityl-H-imidazol-4-yl)pydimidine A 3M solution of ethyl magnesium bromide in diethylether (12.66 mmol) was added to a solution of 4-iodo-1-trityl-1H-imidazole (10.55 mmol) in freshly distilled dry tetrahydrofuran (46.0 mL) in a three necked round bottom flask at room temperature. The reaction mixture was stirred for about 90 minutes and then a 1M solution of zinc chloride (12.66 mmol) was added at room temperature. The solution was stirred for about 90 minutes and then degassed for about 20.0 minutes. Palladium triphenylphosphine (0.61 g, 0.527 mmol) and 5-bromo-2-chloro pyrimidine (11.6 mmol) were added and the reaction mixture was stirred for about 12-14 hrs at about 70 C. The reaction mixture was cooled, diluted with dichloromethane (100.0 mL), washed with aqueous solution of ethylenediaminetetraacetic acid (pH 9), brine, dried over anhydrous sodium sulfate, filtered and concentrated to yield a solid, which was purified by column using ethyl acetate-hexane as eluent to yield the title compound. Yield: 3.0 g (67%).
The synthetic route of 96797-15-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Das, Biswajit; Salman, Mohammad; Kurhade, Santosh Haribhau; Venkataramanan, Ramadass; Kumar, Rajesh; Kapkoti, Gobind Singh; Katoch, Rita; Bandyopadhyay, Anish; Rattan, Ashok; US2009/170790; (2009); A1;,
Imidazole – Wikipedia,
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