Related Products of 54624-57-6, These common heterocyclic compound, 54624-57-6, name is 2-Bromobenzimidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 2-bromobenzimidazole (0.05 g, 0.254 mmol), 2-fluoropyridine-5-boronic acid (0.036 g, 0.254 mmol), Potassium carbonate (0.190 ml, 0.381 mmol), and PdCl2(dppf)2DCM (10.36 mg, 0.013 mmol) in DMF (1.0 mL) was heated at 150 ¡ãC for 15 rain. The crude product was purifled by prepHPLC to afford T452 (6 mg, 11.09 percent).
The synthetic route of 54624-57-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Eli Lilly and Company; Cashion, D.K; chen, G.; Kasi, D; kolb, C; liu, C; sinha, A; Szardenings, A.k; wang, E; yu, C; zhang, W; Gangadharmath, Umesh B; Walsh, J.C; (204 pag.)CN102985411; (2016); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem