Related Products of 88427-96-7,Some common heterocyclic compound, 88427-96-7, name is 4-(2-Methyl-1H-imidazol-1-yl)benzaldehyde, molecular formula is C11H10N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Reference example 5-3 2-Methyl-5-(trifluoromethoxy)-1H-indole To the compound of Reference example 5-2 (2.09 g, 5.69 mmol) were added trifluoroacetic acid (22 ml) and thiosalicylic acid (878 mg, 5.69 mmol), and the mixture was stirred for 3 hours at 50¡ãC. The reaction mixture was diluted with ethyl acetate and neutralized with 1N aqueous sodium hydroxide solution and the mixture was separated by a separating funnel. The organic layer was washed with 1N aqueous sodium hydroxide solution and saturated brine, dried over anhydrous sodium sulfate and filtered. The solvent was removed in vacuo and the residue was purified by silica gel column chromatography to give the subject compound (727 mg, 59 percent). 1H NMR (CDCl3, 400 MHz) delta 7.95 (brs, 1H), 7.35 (brs, 1H), 7.24 (d, 1H, J = 8.7 Hz), 6.97 (brd, 1H, J = 8.7 Hz), 6.24-6.22 (m, 1H), 2.45 (s, 3H).
The synthetic route of 88427-96-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Dainippon Sumitomo Pharma Co., Ltd.; EP1837329; (2007); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem