15965-31-8, name is 5-Chloro-1H-imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 5-Chloro-1H-imidazole
Synthesis of 4-chloro-l-(2-methoxy-4-nitrophenyl)-lH-imidazole [0306] To a stirred solution of l-chloro-2-methoxy-4-nitrobenzene (4 g, 39.21 mmol) in DMSO (40 mL) under argon atmosphere were added 4-chloro-lH-imidazole (7.3 g, 39.21 mmol) and potassium hydroxide (2.2 g, 39.21 mmol) at RT. The reaction mixture was stirred at 80 C for 20 h. After consumption of the starting materials (monitored by TLC), the reaction was diluted with water (600 mL), filtered, washed with water (2 x 50 mL) and dried in vacuo to afford 4-chloro-l-(2-methoxy-4-nitrophenyl)-lH-imidazole (3.8 g, 70%) as a brown solid and used without further purification. 1H-NMR (CDC13, 400 MHz): delta 7.98-7.94 (m, 2H), 7.75 (s, 1H), 7.44 (d, 1H), 7.19 (s, 1H), 4.01 (s, 3H); LC-MS: 254.1 (M+l); (column; X-Bridge C-18 (50 3.0 mm, 3.5 muiotaeta); RT 3.05 min. 0.05% aq TFA: ACN; 0.80 mL/min); TLC: 30% EtOAc:hexanes (R/. 0.5).
The synthetic route of 15965-31-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; FORUM PHARMACEUTICALS INC.; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; MCRINER, Andrew, J.; WO2015/66697; (2015); A1;,
Imidazole – Wikipedia,
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