Simple exploration of 33016-47-6

Reference of 33016-47-6,Some common heterocyclic compound, 33016-47-6, name is 1-Trityl-1H-imidazole-4-carbaldehyde, molecular formula is C23H18N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of methyltriphenylphosphonium bromide (557mg, 1.56mmol) in THF (8mL) was added 1.0 M NaHMDS solution in THF (1.56mL, 1.56mmol) under argon at O0C. The mixture was stirred at this temperature for 30mins followed by the addition of 1-trityl-1H-imidazole-4-carbaldehyde (440mg, 1.3mmol). The reaction was stirred at O0C to room temperature for 3 hours, quenched with saturated aqueous NH4CI solution, extracted with ethyl acetate (3 x 3OmL). The combined organic layers were washed with water, brine, dried over magnesium sulfate, filtered, and concentrated under vacuum. The residue was purified by flash chromatography to give 1-trityl-4-vinyl-1H-imidazole (374 mg) with a yield of 86%.

The synthetic route of 33016-47-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; S BIO PTE LTD; WO2009/93981; (2009); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem