Reference of 22884-10-2, A common heterocyclic compound, 22884-10-2, name is 2-(1H-Imidazol-1-yl)acetic acid, molecular formula is C5H6N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a 50 mL flask was added 4-chloro-orthozide anilide 1d (1 mmol), alpha-bromo-tert-butyl ketone (1.2 mmol), and potassium carbonate (1.5 mmol), which was reacted at 45 C, and the reaction solvent was chloroform ( 20mL), after 2 hours of reaction, Further, diphenylmethylphosphine (1.5 mmol) was added, and the reaction was carried out at 30 C. After the reaction was continued for 3 hours, the solvent chloroform was removed under reduced pressure, and the residue was transferred to triphenylphosphine (2.5 mmol) and iodine. (2.5 mmol) in chloroform (15 mL), Then, imidazoleacetic acid (1.5 mmol) was added, and the reaction was carried out at 45 C for 2 hours. After the reaction was completed, the solvent chloroform was removed under reduced pressure. Residue column chromatography gave 0.206 g of the title compound 2d. The yield was 62%.
The synthetic route of 22884-10-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; China Three Gorges University; Wang Long; Yang Qingqing; Li Yongshuang; Li Dejiang; (8 pag.)CN109265448; (2019); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem