Application of 16042-25-4, These common heterocyclic compound, 16042-25-4, name is 2-Imidazolecarboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
lH-Imidazole-2-carboxylic acid (100 mg, 0.892 mmol), 1,4- dichloro-2-(chloromethyl)benzene (382 mg, 1.96 mmol), and K2C03 (370 mg, 2.68 mmol) were combined in DMF. The suspension was stirred at 100 C for 1 h, then added to 5% aqueous HC1 and extracted with EtOAc. The organic phase was washed with saturated aqueous NaHC03, H20, and brine, then dried over Na2S04 and the solvent removed under reduced pressure. The crude residue was purified by flash- column chromatography using a gradient of DCM : MeOH (100 : 0 to 98 : 2) to give 62a (290 mg, 76%) as a yellow oil.
Statistics shows that 2-Imidazolecarboxylic acid is playing an increasingly important role. we look forward to future research findings about 16042-25-4.
Reference:
Patent; ARDELYX, INC.; LEWIS, Jason, G.; REICH, Nicholas; CHEN, Tao; JACOBS, Jeffrey W.; CHARMOT, Dominique; NAVRE, Marc; FINN, Patricia; CARRERAS, Christopher; SPENCER, Andrew; WO2013/96771; (2013); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem