Electric Literature of 2735-62-8, These common heterocyclic compound, 2735-62-8, name is 2-(1-Methyl-1H-benzo[d]imidazol-2-yl)acetonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 1-methyl-1H benzoimidazol-2-yl)-acetonitrile (4)(23 mg, 0.13 mmol) and 4-methoxy-2-vinyloxy-benzaldehyde (3)(24 mg, 0.13 mmol) in ethanol (4 mL) were treated with one drop ofpiperidine at RT. The solution was stirred for 1 h. No starting wasleft in TLC. The reaction mixture was evaporated. The obtainedcrude mass was purified by column chromatography on silica,product eluted with 10-15% ethyl acetate in hexane to afford 3-(4-methoxy-2-vinyloxy-phenyl)-2-(1-methyl-1H-benzoimidazol-2-yl)-acrylonitrile(VPBA) (20 mg, 44.8%) as yellow solid. 1HNMR(400 MHz, CDCl3): delta (ppm) = 8.39-8.35 (m, 2H), 7.78 (d, J = 7.8 Hz,1H), 7.38-7.30 (m, 3H), 6.75 (d, J = 8.8 Hz, 1H), 6.60-6.56 (m, 2H),4.87 (d, J = 13.64 Hz, 1H), 4.58 (d, J = 5.76 Hz, 1H), 3.99 (s, 3H), 3.87(s, 3H). 13C NMR (100 MHz, CDCl3): 164.03, 157.61, 148.34, 146.96,145.08, 142.46, 136.71, 129.98, 123.58, 122.97, 119.95, 117.32, 115.98,109.68, 108.89, 102.37, 98.23, 97.37, 55.77, 31.63. MS (ESI): m/z calc.for C20H17N3O2: 331.13; found: 332.14 [M + H]+.
The synthetic route of 2735-62-8 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Manna, Srimanta; Karmakar, Parthasarathi; Maiti, Kalipada; Ali, Syed Samim; Mandal, Debasish; Mahapatra, Ajit Kumar; Journal of Photochemistry and Photobiology A: Chemistry; vol. 343; (2017); p. 7 – 16;,
Imidazole – Wikipedia,
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