Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5805-52-7, name is 1H-Benzimidazole-2-carboxamide, A new synthetic method of this compound is introduced below., Computed Properties of C8H7N3O
At room temperature, 3.0 g (18.6 mmol)1H-benzimidazole-2-carboxamide and 7.5 g (18.6 mmol)Lawson reagent placed in 250mL eggplant bottle,Add 150 mL of tetrahydrofuran to reflux at 66 C for 5 h.After the completion of the reaction, the solvent was evaporated to drynessWith methylene chloride dissolved, saturated sodium bicarbonate wash, saturated sodium chloride wash, the organic phase, anhydrous sodium sulfate drying, filtration, columnChromatography to obtain a white solid. Yield: 60.0%.
The synthetic route of 5805-52-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shenyang Pharmaceutical University; Zhao Linxiang; Liu Dan; Li Kun; Wang Shuxiang; Jing Yongkui; (21 pag.)CN106905241; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem