Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 53710-78-4, name is 1-(3-Chloropropyl)-1H-imidazole, A new synthetic method of this compound is introduced below., Recommanded Product: 1-(3-Chloropropyl)-1H-imidazole
Sodium hydride (15 mg, 0.37 mmol) was added to a solution ofcompound 31 (90 mg, 0.31 mmol) in dry 10 mL DMF at 0 C, after 0.5 h,1-(3-chloropropyl)-1H-imidazole (66 mg, 0.47 mmol) was added. Theresultant solution was heated at 65 C for 10 h. After cooling, the solutionwas poured into H2O (50 mL) and then extracted with EtOAc.The organic extracts were washed with brine and dried over Na2SO4.After removal of the solvent, the remaining solid was chromatographedon a silica gel column using CH2Cl2/MeOH (15:1) as eluent to afford asa yellow solid (0.97 g, 78%), mp: 164-166 C. 1H NMR (500 MHz,DMSO-d6) delta 8.76 (s, 1H), 8.59 (s, 1H), 8.38 (s, 1H), 8.16 (d, J=5.2 Hz,1H), 7.65 (s, 1H), 7.55 (d, J=8.5 Hz, 1H), 7.48 (s, 1H), 7.26 (d,J=8.2 Hz, 1H), 7.03 (d, J=5.3 Hz, 1H), 6.86 (s, 2H), 5.43 (s, 1H),4.30 (t, J=6.5 Hz, 2H), 4.22 (t, J=6.5 Hz, 2H), 2.42 (m, 2H), 1.51 (s,6H). HRMS m/z (ESI+): Calculated for C23H24N6OH+ ([M+H]+):401.2090. Found 401.2093
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Ye, Qing; Li, Qiu; Gao, Anhui; Ying, Huazhou; Cheng, Gang; Chen, Jing; Che, Jinxin; Li, Jia; Dong, Xiaowu; Zhou, Yubo; Chemical Physics Letters; vol. 718; (2019); p. 38 – 45;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem