Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 32673-41-9, name is 4-Imidazolemethanol hydrochloride, A new synthetic method of this compound is introduced below., name: 4-Imidazolemethanol hydrochloride
EXAMPLE I To thionyl chloride (170 ml, 2.35 m) stirred at room temperature there was added portion-wise over a ten minute period with exclusion of moisture, 64 g (0.48 m) of 4-hydroxymethylimidazole hydrochloride. With each addition vigorous evolution of gas occurred and occasional cooling by ice/water bath was necessary to keep the temperature below 30 C. The resulting greenish solution was stirred at 30 C. for an additional ten minutes until the gas evolution subsided. The temperature was then raised to 55+-5 C. for forty minutes during which time a thick gelatinous precipitate formed. The reaction mixture was cooled and excess thionyl chloride removed under reduced pressure at 30 C. The yellow residue was triturated with 100 ml of ether, collected and washed four times with 50 ml of ether. The product, a very pale yellow powder, was dried in a stream of air to give 70.88 g (96.5% yield) of 4-chloromethylimidazole hydrochloride m.p. 145-6 C. which was stored under refrigeration. C4 H6 N2 Cl2 requires 31.40% C, 3.95% H, 18.31% N and 46.34% Cl. Elemental analysis found 31.30% C, 4.01% H, 18.34% N and 47.17% Cl.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Polaroid Corporation; US4847383; (1989); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem