Extracurricular laboratory: Synthetic route of 872-82-2

The chemical industry reduces the impact on the environment during synthesis 2-(1H-Imidazol-5-yl)ethanol. I believe this compound will play a more active role in future production and life.

Reference of 872-82-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 872-82-2, name is 2-(1H-Imidazol-5-yl)ethanol, This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 108 2-{[2-(1H-Imidazol-4-yl)ethyl]thio}pyridine 0.5 g (4.4 mmol) of 4-(2-hydroxyethyl)-1H-imidazole and 0.49 g (44.4 mmol) of 2-mercaptopyridine are brought to reflux in 5 ml of 47% aqueous HBr for 24 h. The solvent is removed azeotropically with isopropanol under reduced pressure to provide the title compound in the form of a dihydrobromide monohydrate salt which, after crystallization from isopropanol, melts at 189-190 C.

The chemical industry reduces the impact on the environment during synthesis 2-(1H-Imidazol-5-yl)ethanol. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Institut National de la Sante et de la Recherche Medicale; Societe Civile Bioprojet; US5559113; (1996); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem