Reference of 33016-47-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 33016-47-6, name is 1-Trityl-1H-imidazole-4-carbaldehyde belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Example 34: Preparation of intermediate 8: 1-(1 -trityl-1 W-imidazol-4-yl)ethanolTo a solution of 1 -trityl-1 H-imidazole-4-carbaldehyde (10.0 g, 0.03 mol) in anhydrous THF (100 mL) was added dropwise methyl magnesium bromide (1.4 M in hexane, 52.8 mL, 0.075 mol) at O0C. After the addition, the mixture was stirred at RT overnight. The reaction was quenched with sat. aq. NH4CI (50 mL) and the mixture extracted with CH2CI2 (3*50 mL). The organic layers were combined, washed with 1 N aq. NaOH (3chi20 mL), water (3chi20 mL) and brine (100 mL), dried over MgSO4 and evaporated. The residue was purified via column chromatography {silica gel, EtOAc/Petroleum ether 1 :5) to yield the title compound (8.0 g, 75.0%) as a white solid.
The synthetic route of 1-Trityl-1H-imidazole-4-carbaldehyde has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PFIZER PRODUCTS INC.; WO2008/4096; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem