Application of 1546-79-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1546-79-8 name is 2,2,2-Trifluoro-1-(1H-imidazol-1-yl)ethanone, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
I -(‘rrifliioroacetyl)iniida ole (37.7 p.L, 331 mueta,iotaomicronIota, 6.00 equiv) was added dropwise to a solution of I2-p ~mutilm 94 (17.7 mg. 55.2 mutauetaomicron, 1 equiv) in ethyl acetate (1.0 mL) at -78 C. The resulting mature was stirred for 50 mm a -78 C. The product mixture was diluted with aqueous hydrochloric acid solution (1 , 200 pL) and then was wai’med to 22 C over 1 h. The warmed product .mixture was diluted with aqueous hydrochloric acid solution (.1 M, 1. mL), The diluted product mixture was extracted with ethyl acetate (3 x 5 mL). The organic layers were combined and the combined organic layers were dried over sodiam sulfate. The dried solution was filtered and the. filtrate was concentrated. The residue obtained was purified by preparative thiii-layered chromatography (elutiog with 40% ether-pentaue) to provide the ester S16 as a white solid (15.0 mg, 65%). Rf~ 0.65 (40% ether-pentane, PAA stains purple) H NMR (500 MHz, CDCU) 5.62 (dd, ./= 17.4, 10.8 Hz, 1 H), 5.12-4.98 (m, 3H), 4,39-4.33 (m, IH), 2.53 (p, J – 7.2 Hz, 1H), 2.38-2.03 (m, 4H), 1.82-L66 (m, 3H), 1.60-1.40 (m, 3H), 1.38 (s, 3H 1 -33 (s, 3H), 1.29-1.13 (m, 2H), 0.99 (d, J = 7.1 Hz, 3H 0.83 (d, J = 7.1 Hz, Ml } 5SF NMR (470 MBzs CD?)?-75.09 (s, 3F). ,3C NMR (151 MHz, CDC ) 216.8, 156.8 (q, / – 42.0 Hz), 145,0, 1 14.8 (q, J~ 286.1 Hz), 1 14.0, 80.1, 66.4, 59.2, 46.0, 45.2, 43.8, 42.7, 36.9, 34.9, 34.5, 30.4, 27.3, 25.3, 183, 15.0, 13,5, 1 1 ,6. HRMS-ESI (m/z): calculated for [C22- FjOjN ]”*’ 439.2067, found 439.2046.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,2,2-Trifluoro-1-(1H-imidazol-1-yl)ethanone, and friends who are interested can also refer to it.
Reference:
Patent; YALE UNIVERSITY; HERZON, Seth; MURPHY, Stephen, K.; ZENG, Mingshuo; (194 pag.)WO2018/144717; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem