Electric Literature of 4238-71-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4238-71-5, name is 1-Benzyl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
To a cold (-50 0C) suspension of 1 -benzyl -IH- imidazole (1.58 g, 10.0 ramol) in anhydrous diethyl ether (50 mL) under nitrogen was added ?-butyl lithium (2.5 M in hexanes, 4.0 mL, 10.0 mmol) dropwise. After being stirred for 20 min at -50 0C, dry carbon dioxide (passed through Drierite) was bubbled into the reaction mixture for 10 min before it was allowed to warm up to 25 0C. The heavy precipitate which formed on addition of carbon dioxide to the reaction mixture was filtered to yield a hygroscopic, white solid which was taken up in water (7 mL) , acidified to pH = 3, cooled, and induced to crystallize with scratching. Filtration of the precipitate gave a white solid which was suspended in methanol, treated with IN HCl/diethyl ether (4 mL) and concentrated in vacuo. Lyophilization of the residue from water (5 mL) afforded Cap-136 as a white solid (817 mg, 40%) . 1H NMR (300 MHz, DMSO~d6) 6 7.94 (d, J = 1.5 Hz, IH), 7.71 (d, J = 1.5 Hz, IH) , 7.50-7.31 (m, 5H),5.77 (s, 2H} ; Rt = 0.51 min (Cond. -MS-W5) ; 95% homogenity index; LRMS: Anal. CaIc. for [M+H] + CnH12N2O2: 203.08; found: 203.11.
The synthetic route of 1-Benzyl-1H-imidazole has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; LAVOIE, Rico; BENDER, John A.; BACHAND, Carol; RUEDIGER, Edward H.; KADOW, John F.; WO2010/120621; (2010); A1;,
Imidazole – Wikipedia,
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