Application of 36947-68-9, A common heterocyclic compound, 36947-68-9, name is 2-Isopropyl-1H-imidazole, molecular formula is C6H10N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Reference Example 110: 2-Methyl-2-(3-nitro-phenyl)-propionic acid 2-(2- isopropyl-imidazol-l-yl)-ethyl esterTo a solution of 2-methyl-2-(3-nitro-phenyl)-propionic acid 2-bromo-ethyl ester (1.5_g, 4.74 mmol) in DMF (8 mL) was added sodium iodide (0.73 g, 4.87 mmol) and heated at 100 C for 1 h. 2-Isopropyl-imidazole (2.15 g, 19.5 mmol) and triethylamine (2 mL, 14.6 mmol) were added and then refluxed for 4 h. The reaction was diluted with water and extracted with DCM. The organic layer was-washed thoroughly with water, dried over sodium sulfate and evaporated to obtain crude compound. Purification by column chromatography on silica gel (60-120 mesh), eluting with 30% ethyl acetate/hexane gave 2-methyl-2-(3-nitro-phenyl)-propionic acid 2-(2-isopropyl- imidazol-l-yl)-ethyl ester (320 mg, 20%) as a solid.
The synthetic route of 36947-68-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F2G LTD; WO2008/62182; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem