Synthetic Route of 10040-96-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 10040-96-7 name is 1-(4-Bromophenyl)imidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
22.0g of 1- (4-bromophenyl) -1H-imidazole,27.8g of 10-iodocamphor and 50mL of N, N-dimethylformamide were sequentially added to a three-necked flask equipped with a stirrer, a thermometer and a condensing reflux device.The reaction is carried out at 130 C, and the reaction takes about 4 hours to complete the reaction of one of the raw materials.After cooling, 50 mL of ethyl acetate was added to precipitate the product, and the crude product of camphoryl imidazole iodide was filtered to obtain the target compound by recrystallization from ethanol. The product characterization data is as follows: 80% yield,
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(4-Bromophenyl)imidazole, and friends who are interested can also refer to it.
Reference:
Patent; Nanjing Forestry University; Wang Shifa; Bian Tiancen; Zhao Yuxun; Xu Xu; Yang Yiqin; Gu Wen; (13 pag.)CN110272344; (2019); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem