Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1546-79-8, name is 2,2,2-Trifluoro-1-(1H-imidazol-1-yl)ethanone, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C5H3F3N2O
1,8-Diazabicyclo[5.4,0]undec-7-enium 5′-O-(tert-butyldiphenylsilyl)-3′-O-(tert-butyldimethylsilyl)uridin-3′-yl phosphonate (13u) (100 mumol) is dried by repeated coevaporations with dry pyridine and then dissolved in dry pyridine (1 mL). N,N’-bis(2-oxo-3-oxazolidinyl)phosphinic chloride (BopCl; 500 mumol) is added, and the mixture is stirred for 5 min. To the mixture, a solution of amino alcohol (L-2) (100 mumol), which has been dried by repeated coevaportions with dry pyridine and dissolved in dry pyridine (1 mL), is added dropwise via syringe, and the mixture is stirred for 5 min under argon. 2′,3′-O-bis(tert-butyldimethylsilyl)uridine 9u is dried by repeated coevaporations with dry pyridine and dissolved in 100 mumol pyridine. Then the above mixture is added via cannula into the solution of 2′,3′-O-bis(tert-butyldimethylsilyl)uridine 9u (100 |imol). After 10 min, N-trifluoroacctyl imidazole (CF3COIm; 200 mumol) is added. After an additional 30 s, N,N’-dimethylthiuram disulfide (DTD; 120 mumol) is added. After an additional 3 min, the mixture is dried in vacuum. To the residue, cone NH3-EtOH (3:1, v/v, 10 mL) is added, and the mixture is stirred for 12 h, and then concentrated to dryness under reduced pressure. Then, the mixture is diluted with CHCl3 (5 mL), and washed with 0.2 M phosphate buffer (pH 7.0, 5 mL). The aqueous layers are back-extracted with CHCl3 (2 *5 mL). The combined organic layers are dried over Na2SO4, filtered, and concentrated to dryness under reduced pressure. The residue is purified by PTLC. The product is dissolved in CHCl3 (5 mL), washed with 0.2 M 1,8-diazabicyclo[5.4.0]undec-7-enium bicarbonate buffer (5 mL) and back-extracted with CHCl3 (2*5 mL). The combined organic layers are dried over Na2SO4, filtered, and concentrated to dryness to afford (Sp)-14uu.
According to the analysis of related databases, 1546-79-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ONTORII INCORPORATED; VERDINE, GREGORY L; MEENA, MEENA; IWAMOTO, NAOKI; (250 pag.)JP2015/205910; (2015); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem