Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 870837-18-6, name is 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde, A new synthetic method of this compound is introduced below., Recommanded Product: 870837-18-6
To a solution of intermediate 66 (500 mg, 1.63 mmol) in THF (1 ml) at -75 C was added n-butyl lithium (0.65 ml, 1.63 mmol, 2.5 M in hexanes). The r.m. was stirred for 1 min. at -75 C after which a solution of intermediate 67 (283 mg, 1.31 mmol) in THF (1 ml) was added. The r.m.was then stirred at -75 C for 60 min. and quenched by the addition of a sat. aq. solution of NH4CI (5 ml). The reaction was allowed to warm to r. t. and concentrated under reduced pressure. The residue was purified by flash column chromatography over silica gel (eluent: DCM/MeOH(NH3) from 100/0 to 99/1). The product fractions were collected and concentrated in vacuo, yielding 150 mg of intermediate 68 (21 %).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC; VAN BRANDT, Sven, Franciscus, Anna; DE CLEYN, Michel, Anna, Jozef; GIJSEN, Henricus, Jacobus, Maria; BERTHELOT, Didier, Jean-Claude; SURKYN, Michel; WO2011/86099; (2011); A1;,
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