In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 570-22-9, name is 1H-Imidazole-4,5-dicarboxylic acid belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 1H-Imidazole-4,5-dicarboxylic acid
Into a 100mL round bottom flask, successively added the 1-hydimidazole-4, 5-dicarboxylic acid (600 mg, 1eq, 3.84mmol), thionyl chloride (1.81mL, 6.5eq, 24.8mmol), ultra-dry dimethylformamide (DMF) (0.15mL, 0.5eq, 1.92mmol) and 5mL of toluene, refluxed at 90 C for 16 h. After the reaction, cooling, by using too much toluene in the reaction solution with straw, dissolved in thionyl chloride and DMF aspiration, toluene washed twice and then obtained crude product (compound 1), without further purification directly use for the next step.
The synthetic route of 570-22-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Long Yaqiu; Xu Zhongliang; Wang Heyao; Cai Mengxin; (31 pag.)CN106892871; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem