Adding a certain compound to certain chemical reactions, such as: 26832-08-6, name is 1H-Imidazole-4-carboxamide, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 26832-08-6, category: imidazoles-derivatives
General procedure: To a solution of 4-imidazolecarboxamide (1.94 mmol) in DMF(3 mL) was added NaH (60% in mineral oil, 1.94 mmol) at roomtemperature and the reaction mixture was stirred for 20 min. The methanesulfonate (1.29 mmol) prepared above was added andthe resulting mixture was stirred at 85 C for 3 days. The reactionmixture was cooled, and the insoluble material was filtered andwashed thoroughly with CH2Cl2. The filtrate and washings werecombined and washed with brine. The organic layer was dried overNa2SO4 and concentrated in vacuo. The residue was purified by silicagel column chromatography.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1H-Imidazole-4-carboxamide, and friends who are interested can also refer to it.
Reference:
Article; Kandalkar, Sachin R.; Ramaiah, Parimi Atchuta; Joshi, Manoj; Wavhal, Atul; Waman, Yogesh; Raje, Amol A.; Tambe, Ashwini; Ansari, Shariq; De, Siddhartha; Palle, Venkata P.; Mookhtiar, Kasim A.; Deshpande, Anil M.; Barawkar, Dinesh A.; Bioorganic and Medicinal Chemistry; vol. 25; 20; (2017); p. 5799 – 5819;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem