Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2849-93-6, name is 1H-Benzimidazole-2-carboxylic acid, A new synthetic method of this compound is introduced below., name: 1H-Benzimidazole-2-carboxylic acid
General procedure: To a solution of the commercially available L-leucine tert-butyl ester (12, 0.89mmol) in DMF (15mL) were added an appropriate carboxylic acid (8, 1.1mmol), HOBt¡¤H2O (1.1mmol), and EDC¡¤HCl (1.1mmol). The resulting solution was cooled to 0C under ice bath conditions, and TEA was added dropwise. After 5min, the ice bath was removed, and the mixture was allowed to stir for 2h at ambient temperature. DMF was removed under high vacuum, and the resulting residue was dissolved in EtOAc (30mL). The organic layer was washed with 5% citric acid (20mL¡Á2), 5% NaHCO3 (20mL¡Á2), and brine (20mL). The solution was dried over Na2SO4, filtered, and evaporated under reduced pressure to give compound 13. The resulting crude compound was purified by silica gel column chromatography using hexane-EtOAc as eluents.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Thanigaimalai, Pillaiyar; Konno, Sho; Yamamoto, Takehito; Koiwai, Yuji; Taguchi, Akihiro; Takayama, Kentaro; Yakushiji, Fumika; Akaji, Kenichi; Chen, Shen-En; Naser-Tavakolian, Aurash; Schoen, Arne; Freire, Ernesto; Hayashi, Yoshio; European Journal of Medicinal Chemistry; vol. 68; (2013); p. 372 – 384;,
Imidazole – Wikipedia,
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