Adding a certain compound to certain chemical reactions, such as: 16265-04-6, name is 2-Chloro-1H-imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16265-04-6, HPLC of Formula: C3H3ClN2
Intermediate 77 Sodium hydride (60%> in mineral oils, 468 mg, 11.7 mmol) was added to 2-chloro-lH- imidazole (800 mg, 7.8 mmol) in THF (24 mL) at 0 C. The mixture was stirred at rt for 10 min. Then 2-(trimethylsilyl)ethoxymethyl chloride (2 mL, 11.7 mmol) was added at 0 C and the mixture was stirred for 2 h. The mixture was diluted with sat. sol. NH4C1 and extracted with EtOAc. The organic layer was separated, dried (MgS04), filtered and the solvents evaporated in vacuo. The crude product was purified by flash column chromatography (silica; EtOAc in Heptane 0/100 to 50/50). The desired fractions were collected and the solvents concentrated in vacuo to yield 1-77 (1.52 g, 89%).
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Reference:
Patent; JANSSEN PHARMACEUTICA NV; VAN GOOL, Michiel, Luc, Maria; ALCAZAR-VACA, Manuel, Jesus; ALONSO-DE DIEGO, Sergio-Alvar; DE LUCAS OLIVARES, Ana, Isabel; (105 pag.)WO2016/87487; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem