Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16681-56-4, name is 2-Bromo-1H-imidazole, A new synthetic method of this compound is introduced below., Recommanded Product: 16681-56-4
To a microwave vial was added 6-(2-methoxy-4-(4,4,5,5-tetramethyl-1 ,3,2-5 dioxaborolan-2-yl)phenyi)-N-methyi-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine(Intermediate 9-3, 100 mg, 0.21 mmol), 2-bromo-1 H-imidazole (61.2 mg, 0.42 mmol), Na2C03 (44mg, 0.42 mmol), and Pd(PPh3)2CI2 (14 mg, 0.02 mmol), followed by DME (1 mL)/EtOH 0.25ml)/(H20 (0.25 ml). The vial was purged with N2 for 10 min and the reaction mixture was heated at150C in a microwave reactor for 20 min. The reaction mixture was filtered through celite and the10 filter cake was washed with EtOAc. The filtrate was concentrated in vacuo to give the crude productwhich was purified by silica gel chromatography (5%-15% MeOH/DCM) to afford 6-(4-(1 H-imidazol-2-yl)-2-methoxyphenyi)-N-methyi-N-(2,2,6,6-tetramethylpiperidin-4-yl)pyridazin-3-amine (40 mg,MS: 421.3 [M+H+]).
The synthetic route of 16681-56-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVARTIS AG; CHEUNG, Atwood; CHIN, Donovan Noel; DALES, Natalie; FAZAL, Aleem; HURLEY, Timothy Brian; KERRIGAN, John; O’BRIEN, Gary; SHU, Lei; SUN, Robert; SUNG, Moo; WO2014/28459; (2014); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem