Continuously updated synthesis method about 20485-43-2

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Adding a certain compound to certain chemical reactions, such as: 20485-43-2, name is 1-Methyl-1H-imidazole-2-carboxylic acid, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 20485-43-2, Formula: C5H6N2O2

A solution of the dipyrrole (50 mg, 0.138 mmol) resulting after coupling of the pyrrolicacid 10, as described in the previous experiment, in MeOH:DMF (4.5 mL : 0.7 mL) was hydrogenated for 1 h over 10% palladium on charcoal (30 mg). The catalyst was removed by filtration through celite and the filtrate concentrated. The residue was dissolved in DMF (1.0 mL), cooled to 0 C and added to a solution of acid 12 (13.4 mg,0.106 mmol), DECP (0.04 mL, 0.212 mmol), Et3N (0.13 mL, 0.903 mmol) and DMAP(catalytic) in THF (3.0 mL) at -10 C. The mixture was stirred for 15 h at -10 C. Thesolvents were removed under reduced pressure and the resulting residue purified by flash chromatography (aluminum oxide, 10% MeOH) to give 1b as a yellow-brownsolid (30.7 mg, 66%).

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Reference:
Article; Jimenez-Balsa, Adrian; Dodero, Veronica I.; Mascarenas, Jose L.; Tetrahedron; vol. 69; 36; (2013); p. 7847 – 7853;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem