Introduction of a new synthetic route about 162356-38-9

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 162356-38-9, name is 2-(2-Bromophenyl)-1H-imidazole, This compound has unique chemical properties. The synthetic route is as follows., name: 2-(2-Bromophenyl)-1H-imidazole

Example 20 2-[2-({4-[(2,4-difluorophenoxy)methyl]phenyl}sulfonyl)plienyl]-l/r-imidazole; 2-(2-Bromophenyl)-lH-imidazole (WO 9407486; 1.0 g, 4.48 mmol) was dissolved in TEtaF (11 mL) and DMF (11 mL) and cooled to 00C. Sodium hydride (60percent dispersion in mineral oil, 197 mg, 4.93 mmol) was added and the reaction stirred for 20 min. 2-(Trimethylsilyl)ethoxymethyl chloride (0.79 mL, 4.93 mmol) was added and the reaction stirred overnight at room temperature. The reaction was quenched with MeOH then partitioned between water and Et2O. The organic layer was dried over MgSO4 and EPO concentrated in vacuo. The residue was purified by flash column chromatography, then used according to the method of Example 15 Step 1, followed by SEM-deprotection using trifluoroacetic acid in dichloromethane, to give the title compound. 1H NMR (500 MHz, DMSO): delta 12.10 (1 H, s), 8.24 (1 H, d, J 6.9 Hz), 7.77-7.71 (2 H, m), 7.65 (2 H, d, J 8.0 Hz), 7.53-7.50 (3 H, m), 7.29 (1 H, t, J 8.6 Hz), 7.23- 7.18 (2 H, m), 6.99 (1 H, t, J 7.6 Hz), 6.90 (1 H, s), 5.20 (2 H, s); m/z (ES+) 427 [MH+].

According to the analysis of related databases, 162356-38-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK SHARP & DOHME LIMITED; WO2006/97766; (2006); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem