Electric Literature of 4856-97-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4856-97-7, name is (1H-Benzoimidazol-2-yl)methanol belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
To a three-necked flask was added 1.24 g (6 mmol) of dicyclohexylcarbodiimide, 0.12 g (lmmol) of 4-dimethylaminopyridine, followed by the addition of 25 mL of tetrahydrofuran. After stirring and stirring, 0. 81 g of indole-3-carboxylic acid (5 mmol) After stirring for half an hour at room temperature, 0.75 g (5 mmol) 2-hydroxymethyl benzimidazole, And then stirred at room temperature for 8h, stop the reaction, filtration, steaming the filtrate, drying, and then dissolved in methylene chloride, room temperature conditions, until a large number of green precipitate precipitation, filtration, filter cake washed, vacuum drying 1.10 g (1H-benzimidazol-2-yl) methyl-1H-indole-3-carboxylate in 90.41percent yield.
The synthetic route of (1H-Benzoimidazol-2-yl)methanol has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Qingdao University of Science & Technology; Kang, Congmin; Wang, XinYing; Liu, yizhou; (5 pag.)CN105315262; (2016); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem