Adding a certain compound to certain chemical reactions, such as: 312-73-2, name is 2-(Trifluoromethyl)-1H-benzo[d]imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 312-73-2, Formula: C8H5F3N2
General procedure: mixtureof benzimidazole derivative (0.01 mol, insoluble in H2O) and correspondingacid (0.01 mol, insoluble in H2O) in absolute methanol (25 ml)was stirred at 65 C for 1-3 h. The solvent was distilled off, and theresidue was multiply washed with diethyl ether and dried (24 h) overP2O5 at ~0.01 Torr to afford viscous liquids or powders (soluble in water).Compounds 14, 15 were prepared by the reaction of ion exchange undersimilar conditions for 7-8 h.
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Reference:
Article; Adamovich, Sergei N.; Mirskova, Anna N.; Mirskov, Rudolf G.; Lopyrev, Valentin A.; Mendeleev Communications; vol. 22; 6; (2012); p. 330 – 331;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem