Reference of 33543-78-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 33543-78-1 as follows.
Compound 52 was alkylated in sequence with ethyl bromoacetate, isopentyl iodide, and iodomethane to give compound 55. Hydrolysis of compound 55, followed by a treatment with TMS-Eto-acetylene, gave the cyclic anhydride 57. Reaction of compound 57 with diethyl malonate gave compound 58, which coupled with compound 11 to yield the compound 215.
According to the analysis of related databases, 33543-78-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; INTERMUNE, INC.; US2009/257979; (2009); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem