Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 90871-47-9, name is 2-Amino-1-isopropylbenzimidazole, A new synthetic method of this compound is introduced below., Recommanded Product: 2-Amino-1-isopropylbenzimidazole
General procedure: Sodium (0.29 g, 12.5 mmol) was dissolved in 15 mL of anhydrous ethanol and this solution was concentrated to a small volume (2-3 mL), then 5.0 mmol of the proper 1-substituted 1H-benzimidazol-2-amine 8 and 50.0 mmol (8.00 g) of diethyl malonate were added and the resulting mixture was heated at 150 C (under reflux) with stirring for 3 h. After cooling, the sodium salt of compound 9, which precipitated as a whitish solid during the reaction, was collected, crushed in a mortar, suspended in Et2O, filtered and dried. This solid was then dissolved in water and the resulting solution was acidified with an excess of 6 N aq HCl (or carefully acidified with 6 N aq HCl down to pH 4, in the case of the pyridyl derivatives compounds 9h-k): this way compounds 9a-k separated out as white or whitish solids that were collected by filtration, washed with water, dried and crystallized from the proper solvent. Only in the case of compounds 9l-o (bearing a tertiary amino group on the side chain), the aqueous solution of sodium salt was treated with an excess of 70% aq. HClO4 to get the precipitation of compounds 9l-o as water-insoluble perchlorates which were collected by filtration, washed with water, dried and crystallized from ethanol. According to this procedure the following compounds 9 were obtained (IR and 1H NMR data are reported only for the new compounds).
The synthetic route of 90871-47-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Di Braccio, Mario; Grossi, Giancarlo; Signorello, Maria Grazia; Leoncini, Giuliana; Cichero, Elena; Fossa, Paola; Alfei, Silvana; Damonte, Gianluca; European Journal of Medicinal Chemistry; vol. 62; (2013); p. 564 – 578;,
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