15965-31-8, name is 5-Chloro-1H-imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C3H3ClN2
Example 11 : Preparation of 3-f5-(4-chloroimidazol-1-yl)-2-ethylphenyllbicvclo[3.2.1loctane-2.4- dione and 3-f5-(5-chloroimidazol-1-yl)-2-ethylphenyllbicvclor3.2,Hoctane-2,4-dione3-(5-Bromo-2-ethylphenyl)bicyclo[3.2.1]octane-2,4-dione (100mg, 0.31 mmol), 4-chloroimidazole (47mg, 0.46mmol), potassium phosphate (264mg, 1.24mmol), L-proline (36mg, 0.31 mmol) and copper (I) iodide (60mg, 0.31 mmol) are combined in a microwave vial, suspended in DMSO and heated under microwave irradiation at 1600C for 45 minutes. The mixture is filtered and purified by preparative reverse-phase HPLC to give a mixture of 3-[5-(4-chloroimidazol-1-yl)-2- ethylphenyl]bicyclo[3.2.1]octane-2,4-dione and 3-[5-(5-chloroimidazol-1-yl)-2-ethylphenyl]- bicyclo[3.2.1 ]octane-2,4-dione.
The synthetic route of 15965-31-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SYNGENTA LIMITED; WO2008/145336; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem