Reference of 2466-76-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2466-76-4, name is 1-(1H-Imidazol-1-yl)ethanone belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Step 3; Preparation of N-I (lS, 2R)-l- (3, 5-difluorobenzyl) -2- hydroxy-3- [ (6-iodo-3, 4-dihydro-2H-chromen-4- yl) amino] propyl} acetamide; Tert-butyl (1S, 2R)-1- (3, 5-difluorobenzyl)-2-hydroxy-3- [ (6-iodo- 3,4-dihydro-2H-chromen-4-yl) amino] propylcarbamate (3.0 g, 5.2 mmol) was dissolved in 30 mL of 25percent TFA/CH2Cl2 and stirred at room temperature for 30 min. The mixture was diluted with CH2Cl2 50 mL and washed with NaHC03 (2 x 30 mL). The organic layer was washed with brine (1 x 50 mL) and dried over Na2SO4. The solvent was removed in vacuo and the resulting residue dissolved in 52 mL of CH2Cl2. The mixture was chilled to 0¡ãC followed by the addition of Et3N (1. mL, 11.9 mmol) and acetyl imidazole (0.68 g, 6.2 mmol). The mixture was warm spontaneously over night. The CH2Cl2 was removed in vacuo and the residue dissolved in EtOAc (100 mL) and washed with 1N HC1 (2 x 30 mL), NaHC03 (1 x 30 mL), brine, dried over Na2SO4, and conc. in vacuo to yield 2. 5 g (92percent) of the title compound as a light yellow solid.
The synthetic route of 1-(1H-Imidazol-1-yl)ethanone has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ELAN PHARMACEUTICALS, INC.; PHARMACIA & UP JOHN COMPANY; WO2005/95326; (2005); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem