93-84-5, name is 5-Nitro-1H-benzo[d]imidazol-2(3H)-one, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C7H5N3O3
Preparation 10. 5-amino-1H-benzo[d]imidazol-2(3H)-one[358] A mixture of 5-nitro-2-benzimidazolinone (100 mg, 0.56 mmol), palladium/charcoal (10 mg, 10 wt%), and methanol/ethyl acetate (3 ml / 0.5 ml) was stirred at room temperature under hydrogen atmosphere overnight. The reaction mixture was filtered through a celite pad. The resulting filtrate was concentrated under reduced pressure. The resulting residue was purified with silica gel column chromatography (dichloromethane/methanol = 30/1) to give 85 mg of the titled compound as a red solid.[359] 1H-NMR(400MHz, CD3OD) delta 6.80(d, 1H), 6.52-6.47(m, 2H)
The synthetic route of 93-84-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; YUHAN CORPORATION; SIM, Jae-Young; CHA, Myung-Hun; KIM, Tae-Kyun; LEE, Hyun-Joo; YOON, Young-Ae; KIM, Dong-Hoon; AHN, Hee-Jeong; LEE, Tai-Au; AHN, Kyoung-Kyu; HYUN, Kwan-Hoon; WO2012/115479; (2012); A2;,
Imidazole – Wikipedia,
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