Adding a certain compound to certain chemical reactions, such as: 22884-10-2, name is 2-(1H-Imidazol-1-yl)acetic acid, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 22884-10-2, Computed Properties of C5H6N2O2
Imidazol-1-ylacetic acid (50 gm), phosphorous acid (150 gm) and n-octane (1000 mL) were taken in a four necked round bottom flask fitted with an addition funnel, mechanical stirrer, condenser and thermometer pocket and allowed to stir at 90-95 C. Phosphorus trichloride (250 gm) was then added to the reaction mixture and allowed to heat at 90-95 C.The reaction mixture was cooled and distilled water (500 mL) was added to it. The reaction mixture was further heated to 90-95 C. and then cooled to room temperature, filtered through celite bed. Aqueous layer was separated and methanol (2000 mL) was added to it. The solution was cooled to 0-5 C. and stirred for 4-5 hrs. he precipitated solid was filtered, washed with methanol and dried under vacuum yielding 70 gm of product.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(1H-Imidazol-1-yl)acetic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Pandey, Satish Chandra; Haider, Hussain; Saxena, Sudhanshu; Singh, Manoj Kumar; Thaper, Rajesh Kumar; Dubey, Sushil Kumar; US2009/312551; (2009); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem